Hydrocephalus after Intraventricular Hemorrhage: The Role of Thrombin
نویسندگان
چکیده
منابع مشابه
Hydrocephalus after intraventricular hemorrhage: the role of thrombin.
Previous studies demonstrated that thrombin is an important factor in brain injury after intracerebral hemorrhage. This study investigated the effect of thrombin on hydrocephalus development in a rat intraventricular hemorrhage (IVH) model. There were three parts in this study. First, male Sprague-Dawley rats had an injection of 200 μL saline, autologous blood or heparinized blood, into the rig...
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BACKGROUND AND PURPOSE Severe intraventricular hemorrhage (IVH) in premature infants and the ensuing posthemorrhagic hydrocephalus cause significant mortality and neurological disabilities, and there are currently no effective therapies. This study determined whether intraventricular transplantation of human umbilical cord blood-derived mesenchymal stem cells prevents posthemorrhagic hydrocepha...
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Secondary parkinsonism induced by hydrocephalus after subarachnoid and intraventricular hemorrhage Hydrocephalus can induce secondary parkinsonism (Shahar et al., 1988; Aggarwal et al., 1997; Racette et al., 2004). Physical factors such as increased ventricular pressure near the upper midbrain and basal ganglia are thought to cause mechanical disruption of dopaminergic systems (i.e., the nigros...
متن کاملRole of red blood cell lysis and iron in hydrocephalus after intraventricular hemorrhage.
Thrombin and iron are two major players in intracerebral hemorrhage-induced brain injury and our recent study found that thrombin contributes to hydrocephalus development in a rat model of intraventricular hemorrhage (IVH). This study investigated the role of red blood cell (RBC) lysis and iron in hydrocephalus after IVH. There were three parts to this study. First, male Sprague-Dawley rats rec...
متن کاملIntraventricular hemorrhage and hydrocephalus after spontaneous intracerebral hemorrhage: results from the STICH trial.
INTRODUCTION Intraventricular hemorrhage (IVH), either independent of or as an extension of intracranial bleed, is thought to carry a grave prognosis. Although the effect of IVH on outcome in patients with subarachnoid hemorrhage has been extensively reviewed in the literature, reports of spontaneous intracerebral hemorrhage (ICH) in similar situations have been infrequent. The association of h...
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ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 2013
ISSN: 0271-678X,1559-7016
DOI: 10.1038/jcbfm.2013.225